HEBP2

• Official Symbol: HEBP2
• Official Name: heme binding protein 2
• Aliases and Previous Symbols: N/A
• Entrez ID: 23593
• UniProt: Q9Y5Z4
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. [provided by RefSeq, May 2016].
• UniProt Summary: Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. {ECO:0000269|PubMed:17098234}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 18991
• Expression level (log2 read counts): 2.61

Expression Distribution

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HEBP2 Expression in NALM6 Cells: 2.61