HELB

Entrez Summary: N/A
UniProt Summary: 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates (PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress (PubMed:22194613). {ECO:0000269|PubMed:12181327, ECO:0000269|PubMed:22194613, ECO:0000269|PubMed:25617833, ECO:0000269|PubMed:26774285}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of DNA double-strand break processing
DNA replication, synthesis of RNA primer
5-3 DNA helicase activity
DNA replication factor A complex
single-stranded DNA helicase activity
negative regulation of double-strand break repair via homologous recombination
negative regulation of double-strand break repair
negative regulation of DNA repair
negative regulation of DNA recombination
regulation of double-strand break repair via homologous recombination
site of double-strand break
regulation of double-strand break repair
negative regulation of response to DNA damage stimulus
regulation of DNA recombination
DNA duplex unwinding
DNA geometric change
DNA-dependent DNA replication
negative regulation of DNA metabolic process
regulation of DNA repair
DNA replication
regulation of response to DNA damage stimulus
protein-containing complex binding
DNA conformation change
regulation of DNA metabolic process
DNA repair
RNA biosynthetic process
regulation of cellular response to stress
DNA metabolic process
cellular response to DNA damage stimulus
chromosome organization
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
RNA binding
negative regulation of nucleobase-containing compound metabolic process
regulation of response to stress
ATP binding
negative regulation of response to stimulus
cellular nitrogen compound biosynthetic process