HELLS

Entrez Summary: This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2014].
UniProt Summary: Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). {ECO:0000250|UniProtKB:Q60848}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

pericentric heterochromatin assembly
maintenance of DNA methylation
heterochromatin assembly
methylation-dependent chromatin silencing
pericentric heterochromatin
heterochromatin organization
helicase activity
chromatin remodeling at centromere
centromere complex assembly
chromosome, centromeric region
chromatin silencing
chromatin organization involved in negative regulation of transcription
chromatin organization involved in regulation of transcription
negative regulation of gene expression, epigenetic
lymphocyte proliferation
mononuclear cell proliferation
leukocyte proliferation
chromatin assembly
gene silencing
chromatin assembly or disassembly
chromatin remodeling
DNA packaging
protein-DNA complex assembly
regulation of gene expression, epigenetic
protein-DNA complex subunit organization
DNA conformation change
covalent chromatin modification
lymphocyte activation
cell division
cell population proliferation
chromatin organization
DNA metabolic process
cellular protein-containing complex assembly
leukocyte activation
chromosome organization
cell activation
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process