HERC1

Official Symbol: HERC1
Official Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Aliases and Previous Symbols: N/A
Entrez ID: 8925
UniProt: Q15751
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012].
UniProt Summary: Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cerebellar Purkinje cell differentiation
cerebellar Purkinje cell layer formation
cerebellar Purkinje cell layer morphogenesis
cell differentiation in hindbrain
ARF guanyl-nucleotide exchange factor activity
cerebellar cortex formation
cerebellar Purkinje cell layer development
cerebellar cortex morphogenesis
cerebellum morphogenesis
hindbrain morphogenesis
cerebellar cortex development
neuromuscular process controlling balance
negative regulation of autophagy
cerebellum development
neuromuscular process
metencephalon development
hindbrain development
central nervous system neuron differentiation
ubiquitin-protein transferase activity
negative regulation of cellular catabolic process
negative regulation of catabolic process
regulation of autophagy
neuron projection development
protein ubiquitination
brain development
protein modification by small protein conjugation
head development
neuron development
regulation of cellular catabolic process
anatomical structure formation involved in morphogenesis
central nervous system development
Golgi apparatus
protein modification by small protein conjugation or removal
regulation of catabolic process
neuron differentiation
plasma membrane bounded cell projection organization
cell projection organization
nervous system process
generation of neurons
neurogenesis