HERPUD1
Gene Information
- Official Symbol: HERPUD1
- Official Name: homocysteine inducible ER protein with ubiquitin like domain 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 9709
- UniProt: Q15011
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982). {ECO:0000269|PubMed:16289116, ECO:0000269|PubMed:18307982}.
Pfam Domains GO Terms
Pfam Domains
| ubiquitin |
GO Terms
| Lewy body core |
| protein binding, bridging involved in substrate recognition for ubiquitination |
| positive regulation of ER-associated ubiquitin-dependent protein catabolic process |
| regulation of ER-associated ubiquitin-dependent protein catabolic process |
| PERK-mediated unfolded protein response |
| positive regulation of ERAD pathway |
| endoplasmic reticulum to cytosol transport |
| retrograde protein transport, ER to cytosol |
| negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| endoplasmic reticulum calcium ion homeostasis |
| calcium channel complex |
| protein exit from endoplasmic reticulum |
| regulation of ERAD pathway |
| regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| ER-nucleus signaling pathway |
| positive regulation of response to endoplasmic reticulum stress |
| negative regulation of response to endoplasmic reticulum stress |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of response to endoplasmic reticulum stress |
| ERAD pathway |
| negative regulation of cysteine-type endopeptidase activity |
| negative regulation of intrinsic apoptotic signaling pathway |
| positive regulation of ubiquitin-dependent protein catabolic process |
| positive regulation of proteasomal protein catabolic process |
| endoplasmic reticulum unfolded protein response |
| positive regulation of proteolysis involved in cellular protein catabolic process |
| regulation of proteasomal ubiquitin-dependent protein catabolic process |
| ion channel binding |
| cellular response to unfolded protein |
| positive regulation of cellular protein catabolic process |
| cellular response to topologically incorrect protein |
| regulation of ubiquitin-dependent protein catabolic process |
| regulation of intrinsic apoptotic signaling pathway |
| response to unfolded protein |
| regulation of proteasomal protein catabolic process |
| response to topologically incorrect protein |
| regulation of protein ubiquitination |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of protein catabolic process |
| regulation of proteolysis involved in cellular protein catabolic process |
| negative regulation of apoptotic signaling pathway |
| regulation of protein modification by small protein conjugation or removal |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| regulation of cellular protein catabolic process |
| negative regulation of peptidase activity |
| response to endoplasmic reticulum stress |
| proteasomal protein catabolic process |
| negative regulation of proteolysis |
| positive regulation of proteolysis |
| positive regulation of cellular catabolic process |
| regulation of protein catabolic process |
| regulation of apoptotic signaling pathway |
| regulation of endopeptidase activity |
| positive regulation of catabolic process |
| cellular calcium ion homeostasis |
| regulation of peptidase activity |
| calcium ion homeostasis |
| negative regulation of hydrolase activity |
| cellular divalent inorganic cation homeostasis |
| divalent inorganic cation homeostasis |
| negative regulation of intracellular signal transduction |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| cellular metal ion homeostasis |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| protein catabolic process |
| protein ubiquitination |
| cation homeostasis |
| inorganic ion homeostasis |
| regulation of proteolysis |
| regulation of cellular response to stress |
| cellular chemical homeostasis |
| molecular function |
| protein modification by small protein conjugation |
| ion homeostasis |
| negative regulation of catalytic activity |
| regulation of cellular catabolic process |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| cellular macromolecule catabolic process |
| endoplasmic reticulum membrane |
| protein modification by small protein conjugation or removal |
| regulation of catabolic process |
| negative regulation of cell death |
| intracellular protein transport |
| response to organonitrogen compound |
| endoplasmic reticulum |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| response to nitrogen compound |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| negative regulation of molecular function |
| negative regulation of signal transduction |
| proteolysis |
| regulation of hydrolase activity |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| regulation of apoptotic process |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| negative regulation of response to stimulus |
| homeostatic process |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Lead acetate 2000μM R08 exp497 | -2.13 |
| Golgicide-A 4μM R03 exp122 | -1.71 |
| THZ1 0.06μM R08 exp531 | 1.71 |
| 2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311 | 1.72 |
| WYE-354 6μM R02 exp90 | 1.77 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| MANF | 0.456 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 6/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 5/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1960
- Expression level (log2 read counts): 6.48
Expression Distribution
HERPUD1 Expression in NALM6 Cells: 6.48
