HES3

Entrez Summary: N/A
UniProt Summary: Transcriptional repressor of genes that require a bHLH protein for their transcription. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	1/5

Expression Distribution

trochlear nerve development
midbrain-hindbrain boundary morphogenesis
regulation of timing of neuron differentiation
oculomotor nerve development
midbrain-hindbrain boundary development
rostrocaudal neural tube patterning
regulation of timing of cell differentiation
regulation of development, heterochronic
preganglionic parasympathetic fiber development
parasympathetic nervous system development
neural tube patterning
hindbrain morphogenesis
autonomic nervous system development
cranial nerve development
nerve development
midbrain development
hindbrain development
protein dimerization activity
neural tube development
anterior/posterior pattern specification
DNA-binding transcription repressor activity, RNA polymerase II-specific
RNA polymerase II regulatory region sequence-specific DNA binding
regionalization
transcription factor binding
in utero embryonic development
pattern specification process
RNA polymerase II proximal promoter sequence-specific DNA binding
embryonic morphogenesis
chordate embryonic development
embryo development ending in birth or egg hatching
regulation of neuron differentiation
brain development
head development
regulation of neurogenesis
tube development
negative regulation of transcription by RNA polymerase II
regulation of nervous system development
regulation of cell development
embryo development
central nervous system development