HEXIM2 [The Human Chemical-Genetic Interaction Map Project]

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======= HEXIM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HEXIM2
  * **<color #00a2e8>Official Name</color>**: HEXIM P-TEFb complex subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=124790|124790]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96MH2|Q96MH2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HEXIM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HEXIM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615695|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. {ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15713662}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|snRNA binding|
|7SK snRNA binding|
|cyclin-dependent protein serine/threonine kinase inhibitor activity|
|negative regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of cyclin-dependent protein kinase activity|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|negative regulation of protein serine/threonine kinase activity|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|negative regulation of transferase activity|
|nuclear speck|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|regulation of protein serine/threonine kinase activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|regulation of transferase activity|
|negative regulation of cellular protein metabolic process|
|identical protein binding|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|negative regulation of gene expression|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.86|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.77|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.77|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.73|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.633|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8853
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HEXIM2 Expression in NALM6 Cells: 2.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>