HEXIM2

Gene Information

Official Symbol: HEXIM2
Official Name: HEXIM P-TEFb complex subunit 2
Aliases and Previous Symbols: N/A
Entrez ID: 124790
UniProt: Q96MH2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. {ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15713662}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tanespimycin 14μM R08 exp527	-1.86
ONC212 0.15μM R08 exp513	-1.77
PU-H71 1μM R08 exp515	-1.77
Nocodazole 0.2μM R00 exp24	-1.73
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.74

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8853
Expression level (log2 read counts): 2.62

Expression Distribution

snRNA binding
7SK snRNA binding
cyclin-dependent protein serine/threonine kinase inhibitor activity
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cyclin-dependent protein kinase activity
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
negative regulation of protein serine/threonine kinase activity
negative regulation of protein kinase activity
negative regulation of kinase activity
negative regulation of transferase activity
nuclear speck
negative regulation of protein phosphorylation
negative regulation of phosphorylation
regulation of protein serine/threonine kinase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of cell cycle
negative regulation of protein modification process
negative regulation of catalytic activity
regulation of protein kinase activity
negative regulation of transcription by RNA polymerase II
regulation of kinase activity
regulation of transferase activity
negative regulation of cellular protein metabolic process
identical protein binding
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of cell cycle
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
regulation of protein phosphorylation
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
regulation of phosphorylation