HEY1

Official Symbol: HEY1
Official Name: hes related family bHLH transcription factor with YRPW motif 1
Aliases and Previous Symbols: N/A
Entrez ID: 23462
UniProt: Q9Y5J3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). {ECO:0000250|UniProtKB:Q9WV93, ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:15485867, ECO:0000269|PubMed:25985737}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Hairy orange
HLH

umbilical cord development
umbilical cord morphogenesis
negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
arterial endothelial cell differentiation
blood vessel endothelial cell differentiation
atrioventricular valve formation
dorsal aorta morphogenesis
dorsal aorta development
Notch signaling involved in heart development
heart valve formation
heart trabecula formation
regulation of vasculogenesis
pulmonary valve morphogenesis
labyrinthine layer blood vessel development
negative regulation of transcription regulatory region DNA binding
pulmonary valve development
trabecula formation
atrioventricular valve morphogenesis
cell surface receptor signaling pathway involved in heart development
atrioventricular valve development
negative regulation of biomineralization
cardiac epithelial to mesenchymal transition
negative regulation of biomineral tissue development
aorta morphogenesis
placenta blood vessel development
smooth muscle cell differentiation
heart trabecula morphogenesis
endocardial cushion morphogenesis
semi-lunar valve development
ventricular septum morphogenesis
negative regulation of Notch signaling pathway
endocardial cushion development
trabecula morphogenesis
labyrinthine layer development
mesenchyme morphogenesis
aorta development
heart valve morphogenesis
regulation of transcription regulatory region DNA binding
negative regulation of DNA binding
artery morphogenesis