HEY2
Gene Information
- Official Symbol: HEY2
- Official Name: hes related family bHLH transcription factor with YRPW motif 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 23493
- UniProt: Q9UBP5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'- CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. {ECO:0000269|PubMed:10692439, ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:15485867, ECO:0000269|PubMed:16293227}.
Pfam Domains GO Terms
Pfam Domains
| Hairy orange |
| HLH |
GO Terms
| negative regulation of cardiac vascular smooth muscle cell differentiation |
| tricuspid valve formation |
| umbilical cord morphogenesis |
| umbilical cord development |
| endocardial cushion to mesenchymal transition involved in heart valve formation |
| negative regulation of transcription by transcription factor localization |
| cardiac vascular smooth muscle cell development |
| negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation |
| regulation of cardiac vascular smooth muscle cell differentiation |
| ascending aorta morphogenesis |
| tricuspid valve morphogenesis |
| endocardial cushion to mesenchymal transition |
| negative regulation of transcription initiation from RNA polymerase II promoter |
| ascending aorta development |
| arterial endothelial cell differentiation |
| muscular septum morphogenesis |
| tricuspid valve development |
| negative regulation of DNA-templated transcription, initiation |
| pulmonary artery morphogenesis |
| cardiac vascular smooth muscle cell differentiation |
| negative regulation of vascular smooth muscle cell differentiation |
| regulation of inner ear auditory receptor cell differentiation |
| blood vessel endothelial cell differentiation |
| dorsal aorta morphogenesis |
| regulation of inner ear receptor cell differentiation |
| atrioventricular valve formation |
| regulation of mechanoreceptor differentiation |
| vascular smooth muscle cell development |
| dorsal aorta development |
| ventricular cardiac muscle cell development |
| Notch signaling involved in heart development |
| heart valve formation |
| heart trabecula formation |
| epithelial to mesenchymal transition involved in endocardial cushion formation |
| muscle hypertrophy in response to stress |
| regulation of vascular smooth muscle cell differentiation |
| cardiac muscle hypertrophy in response to stress |
| vascular smooth muscle cell differentiation |
| cardiac muscle adaptation |
| regulation of vasculogenesis |
| Sin3 complex |
| cardiac left ventricle morphogenesis |
| negative regulation of smooth muscle cell differentiation |
| atrial septum morphogenesis |
| coronary vasculature morphogenesis |
| ventricular cardiac muscle cell differentiation |
| ventricular trabecula myocardium morphogenesis |
| pulmonary valve morphogenesis |
| labyrinthine layer blood vessel development |
| cardiac right ventricle morphogenesis |
| endocardial cushion formation |
| negative regulation of cardiocyte differentiation |
| pulmonary valve development |
| atrial septum development |
| negative regulation of transcription regulatory region DNA binding |
| negative regulation of cardiac muscle cell apoptotic process |
| trabecula formation |
| atrioventricular valve morphogenesis |
| cell surface receptor signaling pathway involved in heart development |
| positive regulation of heart rate |
| negative regulation of striated muscle cell apoptotic process |
| positive regulation of cardiac muscle cell proliferation |
| atrioventricular valve development |
| regulation of transcription initiation from RNA polymerase II promoter |
| striated muscle adaptation |
| negative regulation of biomineralization |
| cardiac epithelial to mesenchymal transition |
| negative regulation of biomineral tissue development |
| aorta morphogenesis |
| aortic valve morphogenesis |
| cardiac muscle hypertrophy |
| cardiac atrium morphogenesis |
| placenta blood vessel development |
| striated muscle hypertrophy |
| regulation of smooth muscle cell differentiation |
| heart trabecula morphogenesis |
| muscle hypertrophy |
| muscle adaptation |
| smooth muscle cell differentiation |
| aortic valve development |
| positive regulation of cardiac muscle tissue growth |
| endocardial cushion morphogenesis |
| cardiac atrium development |
| regulation of DNA-templated transcription, initiation |
| negative regulation of muscle cell apoptotic process |
| semi-lunar valve development |
| positive regulation of heart growth |
| regulation of cardiac muscle cell apoptotic process |
| positive regulation of heart contraction |
| regulation of striated muscle cell apoptotic process |
| regulation of cardiac muscle cell proliferation |
| ventricular septum morphogenesis |
| negative regulation of Notch signaling pathway |
| endocardial cushion development |
| positive regulation of cardiac muscle tissue development |
| trabecula morphogenesis |
| coronary vasculature development |
| labyrinthine layer development |
| positive regulation of organ growth |
| ventricular cardiac muscle tissue morphogenesis |
| anterior/posterior axis specification |
| regulation of cardiocyte differentiation |
| mesenchyme morphogenesis |
| aorta development |
| cochlea development |
| heart valve morphogenesis |
| regulation of transcription regulatory region DNA binding |
| RNA polymerase II activating transcription factor binding |
| negative regulation of muscle cell differentiation |
| negative regulation of DNA binding |
| ventricular cardiac muscle tissue development |
| transcriptional repressor complex |
| regulation of cardiac muscle tissue growth |
| cardiac muscle cell development |
| regulation of epidermal cell differentiation |
| artery morphogenesis |
| heart valve development |
| regulation of heart growth |
| cardiac cell development |
| cardiac muscle tissue morphogenesis |
| vasculogenesis |
| regulation of muscle cell apoptotic process |
| positive regulation of muscle organ development |
| positive regulation of striated muscle tissue development |
| positive regulation of blood circulation |
| positive regulation of muscle tissue development |
| epithelial to mesenchymal transition |
| ventricular septum development |
| cardiac ventricle morphogenesis |
| cardiac septum morphogenesis |
| outflow tract morphogenesis |
| regulation of cardiac muscle tissue development |
| muscle tissue morphogenesis |
| endothelial cell differentiation |
| mesenchymal cell development |
| axis specification |
| artery development |
| regulation of epidermis development |
| muscle organ morphogenesis |
| embryonic placenta development |
| cardiac muscle cell differentiation |
| regulation of biomineralization |
| regulation of biomineral tissue development |
| regulation of organ growth |
| endothelium development |
| regulation of heart rate |
| regulation of Notch signaling pathway |
| cardiac septum development |
| histone deacetylase binding |
| cardiocyte differentiation |
| negative regulation of vasculature development |
| Notch signaling pathway |
| regulation of DNA binding |
| cardiac chamber morphogenesis |
| cardiac ventricle development |
| regulation of striated muscle tissue development |
| striated muscle cell development |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| regulation of epithelial cell differentiation |
| muscle cell development |
| placenta development |
| regulation of muscle cell differentiation |
| mesenchymal cell differentiation |
| cardiac muscle tissue development |
| negative regulation of binding |
| cardiac chamber development |
| positive regulation of developmental growth |
| inner ear development |
| striated muscle cell differentiation |
| protein-DNA complex assembly |
| anterior/posterior pattern specification |
| mesenchyme development |
| ear development |
| protein-DNA complex subunit organization |
| regulation of heart contraction |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| muscle cell differentiation |
| cell fate commitment |
| heart morphogenesis |
| positive regulation of growth |
| striated muscle tissue development |
| regulation of blood circulation |
| muscle organ development |
| muscle tissue development |
| muscle system process |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| regulation of vasculature development |
| regulation of developmental growth |
| transcription factor binding |
| regionalization |
| in utero embryonic development |
| regulation of binding |
| blood vessel morphogenesis |
| sequence-specific DNA binding |
| reproductive structure development |
| reproductive system development |
| embryonic organ development |
| pattern specification process |
| muscle structure development |
| blood vessel development |
| protein heterodimerization activity |
| vasculature development |
| cardiovascular system development |
| heart development |
| sensory organ development |
| tissue morphogenesis |
| regulation of system process |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| regulation of neuron differentiation |
| developmental process involved in reproduction |
| regulation of growth |
| DNA-binding transcription factor activity |
| epithelial cell differentiation |
| negative regulation of cell differentiation |
| regulation of neurogenesis |
| cellular protein-containing complex assembly |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| protein homodimerization activity |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| animal organ morphogenesis |
| embryo development |
| negative regulation of cell death |
| regulation of anatomical structure morphogenesis |
| epithelium development |
| negative regulation of molecular function |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| cellular protein localization |
| cellular macromolecule localization |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of cell death |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Oligomycin-A 2μM R00 exp25 | -1.98 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17867
- Expression level (log2 read counts): -0.69
Expression Distribution
HEY2 Expression in NALM6 Cells: -0.69
