HIST1H3A
Gene Information
- Official Symbol: H3C1
- Official Name: H3 clustered histone 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 8350
- UniProt: P68431
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Histone |
GO Terms
| DNA replication-dependent nucleosome assembly |
| DNA replication-dependent nucleosome organization |
| chromatin silencing at rDNA |
| nuclear nucleosome |
| interleukin-7-mediated signaling pathway |
| nuclear chromosome |
| response to interleukin-7 |
| cellular response to interleukin-7 |
| protein heterotetramerization |
| nucleosomal DNA binding |
| regulation of megakaryocyte differentiation |
| chromatin organization involved in negative regulation of transcription |
| chromatin silencing |
| nucleosome |
| chromatin organization involved in regulation of transcription |
| negative regulation of gene expression, epigenetic |
| regulation of gene silencing by miRNA |
| regulation of gene silencing by RNA |
| regulation of posttranscriptional gene silencing |
| telomere organization |
| protein heterooligomerization |
| nucleosome assembly |
| regulation of gene silencing |
| chromatin assembly |
| protein tetramerization |
| gene silencing |
| chromatin assembly or disassembly |
| nucleosome organization |
| DNA packaging |
| protein-DNA complex assembly |
| regulation of myeloid cell differentiation |
| regulation of gene expression, epigenetic |
| protein-DNA complex subunit organization |
| blood coagulation |
| coagulation |
| DNA conformation change |
| hemostasis |
| cadherin binding |
| regulation of hemopoiesis |
| wound healing |
| protein heterodimerization activity |
| regulation of body fluid levels |
| protein complex oligomerization |
| response to wounding |
| protein-containing complex |
| cytokine-mediated signaling pathway |
| chromatin organization |
| cellular protein-containing complex assembly |
| cellular response to cytokine stimulus |
| chromosome organization |
| response to cytokine |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| regulation of immune system process |
| negative regulation of gene expression |
| regulation of cell differentiation |
| protein-containing complex subunit organization |
| extracellular region |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7245
- Expression level (log2 read counts): -1.17
Expression Distribution
HIST1H3A Expression in NALM6 Cells: -1.17
