HLA-DMB

Gene Information

Official Symbol: HLA-DMB
Official Name: major histocompatibility complex, class II, DM beta
Aliases and Previous Symbols: N/A
Entrez ID: 3109
UniProt: P28068
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:8849454, ECO:0000269|PubMed:9768757}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15418
Expression level (log2 read counts): 5.96

Expression Distribution

MHC II beta
C1-set

MHC class II protein complex assembly
peptide antigen assembly with MHC class II protein complex
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
peptide antigen assembly with MHC protein complex
regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
MHC protein complex assembly
MHC class II protein complex
MHC class II protein complex binding
positive regulation of T cell proliferation
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
late endosome membrane
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
positive regulation of leukocyte proliferation
regulation of T cell proliferation
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
positive regulation of T cell activation
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
antigen processing and presentation
positive regulation of leukocyte cell-cell adhesion
positive regulation of immune effector process
regulation of leukocyte proliferation
positive regulation of cell-cell adhesion
regulation of leukocyte cell-cell adhesion
lysosomal membrane
regulation of T cell activation
positive regulation of lymphocyte activation
regulation of cell-cell adhesion
positive regulation of cell adhesion
positive regulation of leukocyte activation
positive regulation of cell activation
regulation of immune effector process
regulation of lymphocyte activation
regulation of leukocyte activation
adaptive immune response