HLA-E [The Human Chemical-Genetic Interaction Map Project]

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======= HLA-E =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HLA-E
  * **<color #00a2e8>Official Name</color>**: major histocompatibility complex, class I, E
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3133|3133]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13747|P13747]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HLA-E&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HLA-E|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/143010|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1-set|
|MHC I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of antibody-dependent cellular cytotoxicity|
|MHC class Ib protein complex|
|positive regulation of TRAIL production|
|positive regulation of CD8-positive, alpha-beta T cell proliferation|
|regulation of antibody-dependent cellular cytotoxicity|
|regulation of TRAIL production|
|positive regulation of type IIa hypersensitivity|
|positive regulation of type II hypersensitivity|
|natural killer cell tolerance induction|
|antigen processing and presentation of exogenous peptide antigen via MHC class Ib|
|regulation of type IIa hypersensitivity|
|protection from natural killer cell mediated cytotoxicity|
|regulation of type II hypersensitivity|
|positive regulation of CD8-positive, alpha-beta T cell activation|
|positive regulation of hypersensitivity|
|regulation of CD8-positive, alpha-beta T cell proliferation|
|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway|
|T cell receptor binding|
|positive regulation of natural killer cell proliferation|
|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|
|positive regulation of natural killer cell cytokine production|
|regulation of hypersensitivity|
|antigen processing and presentation of endogenous peptide antigen via MHC class Ib|
|regulation of natural killer cell cytokine production|
|positive regulation of acute inflammatory response to antigenic stimulus|
|beta-2-microglobulin binding|
|antigen processing and presentation of peptide antigen via MHC class Ib|
|natural killer cell lectin-like receptor binding|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|
|regulation of natural killer cell proliferation|
|CD8-positive, alpha-beta T cell activation|
|MHC class I protein complex|
|positive regulation of immunoglobulin secretion|
|positive regulation of inflammatory response to antigenic stimulus|
|tolerance induction|
|regulation of acute inflammatory response to antigenic stimulus|
|negative regulation of natural killer cell mediated cytotoxicity|
|antigen processing and presentation of endogenous peptide antigen via MHC class I|
|antigen processing and presentation of endogenous peptide antigen|
|negative regulation of natural killer cell mediated immunity|
|regulation of CD8-positive, alpha-beta T cell activation|
|positive regulation of interleukin-13 production|
|antigen processing and presentation via MHC class Ib|
|negative regulation of leukocyte mediated cytotoxicity|
|MHC class I protein binding|
|positive regulation of alpha-beta T cell proliferation|
|regulation of immunoglobulin secretion|
|positive regulation of natural killer cell activation|
|antigen processing and presentation of endogenous antigen|
|negative regulation of cell killing|
|regulation of interleukin-13 production|
|positive regulation of interleukin-4 production|
|regulation of inflammatory response to antigenic stimulus|
|positive regulation of T cell mediated cytotoxicity|
|regulation of interleukin-4 production|
|positive regulation of acute inflammatory response|
|positive regulation of natural killer cell mediated cytotoxicity|
|integral component of lumenal side of endoplasmic reticulum membrane|
|regulation of alpha-beta T cell proliferation|
|positive regulation of myeloid leukocyte mediated immunity|
|positive regulation of natural killer cell mediated immunity|
|regulation of natural killer cell activation|
|peptide antigen binding|
|regulation of T cell mediated cytotoxicity|
|positive regulation of immunoglobulin mediated immune response|
|positive regulation of B cell mediated immunity|
|negative regulation of lymphocyte mediated immunity|
|antibacterial humoral response|
|regulation of natural killer cell mediated cytotoxicity|
|positive regulation of immunoglobulin production|
|regulation of acute inflammatory response|
|regulation of natural killer cell mediated immunity|
|positive regulation of T cell mediated immunity|
|negative regulation of leukocyte mediated immunity|
|regulation of immunoglobulin mediated immune response|
|regulation of B cell mediated immunity|
|positive regulation of cytokine production involved in immune response|
|ER to Golgi transport vesicle membrane|
|positive regulation of leukocyte mediated cytotoxicity|
|negative regulation of innate immune response|
|regulation of myeloid leukocyte mediated immunity|
|positive regulation of alpha-beta T cell activation|
|alpha-beta T cell activation|
|regulation of immunoglobulin production|
|type I interferon signaling pathway|
|cellular response to type I interferon|
|positive regulation of cell killing|
|regulation of T cell mediated immunity|
|response to type I interferon|
|interferon-gamma-mediated signaling pathway|
|phagocytic vesicle membrane|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|regulation of leukocyte mediated cytotoxicity|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|recycling endosome membrane|
|regulation of cytokine production involved in immune response|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|negative regulation of response to biotic stimulus|
|regulation of alpha-beta T cell activation|
|defense response to Gram-positive bacterium|
|positive regulation of T cell proliferation|
|positive regulation of production of molecular mediator of immune response|
|antigen processing and presentation of peptide antigen via MHC class I|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cell killing|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|antimicrobial humoral response|
|negative regulation of immune effector process|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte mediated immunity|
|positive regulation of leukocyte proliferation|
|positive regulation of inflammatory response|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of tumor necrosis factor production|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|early endosome membrane|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|cellular response to interferon-gamma|
|antigen processing and presentation of exogenous peptide antigen|
|response to interferon-gamma|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|negative regulation of defense response|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|negative regulation of multi-organism process|
|positive regulation of leukocyte cell-cell adhesion|
|antigen processing and presentation|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|T cell activation|
|positive regulation of cell-cell adhesion|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|defense response to bacterium|
|signaling receptor binding|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|humoral immune response|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|negative regulation of response to external stimulus|
|lymphocyte activation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of protein transport|
|positive regulation of secretion|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of defense response|
|regulation of peptide secretion|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|adaptive immune response|
|cell surface|
|Golgi membrane|
|regulation of cell activation|
|immune system development|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|regulation of secretion|
|positive regulation of immune response|
|positive regulation of cell population proliferation|
|leukocyte activation|
|defense response to other organism|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|cell activation|
|regulation of response to external stimulus|
|response to cytokine|
|regulation of immune response|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.74|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16355
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HLA-E Expression in NALM6 Cells: 7.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>