HLA-E
Gene Information
- Official Symbol: HLA-E
- Official Name: major histocompatibility complex, class I, E
- Aliases and Previous Symbols: N/A
- Entrez ID: 3133
- UniProt: P13747
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules.
Pfam Domains GO Terms
Pfam Domains
| C1-set |
| MHC I |
GO Terms
| positive regulation of antibody-dependent cellular cytotoxicity |
| MHC class Ib protein complex |
| positive regulation of TRAIL production |
| positive regulation of CD8-positive, alpha-beta T cell proliferation |
| regulation of antibody-dependent cellular cytotoxicity |
| regulation of TRAIL production |
| positive regulation of type IIa hypersensitivity |
| positive regulation of type II hypersensitivity |
| natural killer cell tolerance induction |
| antigen processing and presentation of exogenous peptide antigen via MHC class Ib |
| regulation of type IIa hypersensitivity |
| protection from natural killer cell mediated cytotoxicity |
| regulation of type II hypersensitivity |
| positive regulation of CD8-positive, alpha-beta T cell activation |
| positive regulation of hypersensitivity |
| regulation of CD8-positive, alpha-beta T cell proliferation |
| antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway |
| T cell receptor binding |
| positive regulation of natural killer cell proliferation |
| antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent |
| positive regulation of natural killer cell cytokine production |
| regulation of hypersensitivity |
| antigen processing and presentation of endogenous peptide antigen via MHC class Ib |
| regulation of natural killer cell cytokine production |
| positive regulation of acute inflammatory response to antigenic stimulus |
| beta-2-microglobulin binding |
| antigen processing and presentation of peptide antigen via MHC class Ib |
| natural killer cell lectin-like receptor binding |
| antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent |
| regulation of natural killer cell proliferation |
| CD8-positive, alpha-beta T cell activation |
| MHC class I protein complex |
| positive regulation of immunoglobulin secretion |
| positive regulation of inflammatory response to antigenic stimulus |
| tolerance induction |
| regulation of acute inflammatory response to antigenic stimulus |
| negative regulation of natural killer cell mediated cytotoxicity |
| antigen processing and presentation of endogenous peptide antigen via MHC class I |
| antigen processing and presentation of endogenous peptide antigen |
| negative regulation of natural killer cell mediated immunity |
| regulation of CD8-positive, alpha-beta T cell activation |
| positive regulation of interleukin-13 production |
| antigen processing and presentation via MHC class Ib |
| negative regulation of leukocyte mediated cytotoxicity |
| MHC class I protein binding |
| positive regulation of alpha-beta T cell proliferation |
| regulation of immunoglobulin secretion |
| positive regulation of natural killer cell activation |
| antigen processing and presentation of endogenous antigen |
| negative regulation of cell killing |
| regulation of interleukin-13 production |
| positive regulation of interleukin-4 production |
| regulation of inflammatory response to antigenic stimulus |
| positive regulation of T cell mediated cytotoxicity |
| regulation of interleukin-4 production |
| positive regulation of acute inflammatory response |
| positive regulation of natural killer cell mediated cytotoxicity |
| integral component of lumenal side of endoplasmic reticulum membrane |
| regulation of alpha-beta T cell proliferation |
| positive regulation of myeloid leukocyte mediated immunity |
| positive regulation of natural killer cell mediated immunity |
| regulation of natural killer cell activation |
| peptide antigen binding |
| regulation of T cell mediated cytotoxicity |
| positive regulation of immunoglobulin mediated immune response |
| positive regulation of B cell mediated immunity |
| negative regulation of lymphocyte mediated immunity |
| antibacterial humoral response |
| regulation of natural killer cell mediated cytotoxicity |
| positive regulation of immunoglobulin production |
| regulation of acute inflammatory response |
| regulation of natural killer cell mediated immunity |
| positive regulation of T cell mediated immunity |
| negative regulation of leukocyte mediated immunity |
| regulation of immunoglobulin mediated immune response |
| regulation of B cell mediated immunity |
| positive regulation of cytokine production involved in immune response |
| ER to Golgi transport vesicle membrane |
| positive regulation of leukocyte mediated cytotoxicity |
| negative regulation of innate immune response |
| regulation of myeloid leukocyte mediated immunity |
| positive regulation of alpha-beta T cell activation |
| alpha-beta T cell activation |
| regulation of immunoglobulin production |
| type I interferon signaling pathway |
| cellular response to type I interferon |
| positive regulation of cell killing |
| regulation of T cell mediated immunity |
| response to type I interferon |
| interferon-gamma-mediated signaling pathway |
| phagocytic vesicle membrane |
| antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| regulation of leukocyte mediated cytotoxicity |
| antigen processing and presentation of exogenous peptide antigen via MHC class I |
| recycling endosome membrane |
| regulation of cytokine production involved in immune response |
| positive regulation of tumor necrosis factor production |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| negative regulation of response to biotic stimulus |
| regulation of alpha-beta T cell activation |
| defense response to Gram-positive bacterium |
| positive regulation of T cell proliferation |
| positive regulation of production of molecular mediator of immune response |
| antigen processing and presentation of peptide antigen via MHC class I |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of cell killing |
| positive regulation of adaptive immune response |
| positive regulation of lymphocyte mediated immunity |
| antimicrobial humoral response |
| negative regulation of immune effector process |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| positive regulation of leukocyte mediated immunity |
| positive regulation of leukocyte proliferation |
| positive regulation of inflammatory response |
| regulation of production of molecular mediator of immune response |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of tumor necrosis factor production |
| negative regulation of immune response |
| regulation of lymphocyte mediated immunity |
| early endosome membrane |
| regulation of tumor necrosis factor superfamily cytokine production |
| regulation of T cell proliferation |
| regulation of adaptive immune response |
| cellular response to interferon-gamma |
| antigen processing and presentation of exogenous peptide antigen |
| response to interferon-gamma |
| antigen processing and presentation of exogenous antigen |
| antigen processing and presentation of peptide antigen |
| positive regulation of T cell activation |
| regulation of leukocyte mediated immunity |
| negative regulation of defense response |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| negative regulation of multi-organism process |
| positive regulation of leukocyte cell-cell adhesion |
| antigen processing and presentation |
| positive regulation of immune effector process |
| regulation of leukocyte proliferation |
| T cell activation |
| positive regulation of cell-cell adhesion |
| positive regulation of protein secretion |
| positive regulation of peptide secretion |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| defense response to bacterium |
| signaling receptor binding |
| regulation of inflammatory response |
| positive regulation of innate immune response |
| humoral immune response |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| negative regulation of response to external stimulus |
| lymphocyte activation |
| external side of plasma membrane |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of secretion by cell |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| positive regulation of protein transport |
| positive regulation of secretion |
| negative regulation of immune system process |
| positive regulation of cytokine production |
| regulation of innate immune response |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of immune effector process |
| positive regulation of defense response |
| regulation of peptide secretion |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| regulation of response to biotic stimulus |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| adaptive immune response |
| cell surface |
| Golgi membrane |
| regulation of cell activation |
| immune system development |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| response to bacterium |
| regulation of cytokine production |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| innate immune response |
| regulation of multi-organism process |
| regulation of secretion |
| positive regulation of immune response |
| positive regulation of cell population proliferation |
| leukocyte activation |
| defense response to other organism |
| positive regulation of transport |
| cellular response to cytokine stimulus |
| regulation of protein localization |
| cell activation |
| regulation of response to external stimulus |
| response to cytokine |
| regulation of immune response |
| positive regulation of immune system process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| regulation of response to stress |
| extracellular space |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| positive regulation of multicellular organismal process |
| regulation of transport |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Lapatinib 5μM R01 exp47 | -1.74 |
| BVD-523 15μM R02 exp67 | 1.94 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16355
- Expression level (log2 read counts): 7.74
Expression Distribution
HLA-E Expression in NALM6 Cells: 7.74
