HLA-F
Gene Information
- Official Symbol: HLA-F
- Official Name: major histocompatibility complex, class I, F
- Aliases and Previous Symbols: N/A
- Entrez ID: 3134
- UniProt: P30511
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| C1-set |
| MHC I |
GO Terms
| negative regulation of natural killer cell degranulation |
| MHC class Ib protein complex |
| negative regulation of natural killer cell cytokine production |
| antigen processing and presentation of exogenous peptide antigen via MHC class Ib |
| regulation of natural killer cell degranulation |
| positive regulation of natural killer cell degranulation |
| TAP1 binding |
| TAP2 binding |
| antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway |
| antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent |
| positive regulation of natural killer cell cytokine production |
| antigen processing and presentation of endogenous peptide antigen via MHC class Ib |
| regulation of natural killer cell cytokine production |
| beta-2-microglobulin binding |
| negative regulation of natural killer cell activation |
| antigen processing and presentation of peptide antigen via MHC class Ib |
| negative regulation of T cell cytokine production |
| antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent |
| MHC class I protein complex |
| negative regulation of leukocyte degranulation |
| antigen processing and presentation of endogenous peptide antigen via MHC class I |
| negative regulation of natural killer cell mediated cytotoxicity |
| antigen processing and presentation of endogenous peptide antigen |
| negative regulation of natural killer cell mediated immunity |
| antigen processing and presentation via MHC class Ib |
| negative regulation of leukocyte mediated cytotoxicity |
| negative regulation of T cell mediated immunity |
| positive regulation of natural killer cell activation |
| antigen processing and presentation of endogenous antigen |
| negative regulation of cell killing |
| positive regulation of leukocyte degranulation |
| negative regulation of cytokine production involved in immune response |
| negative regulation of regulated secretory pathway |
| positive regulation of T cell mediated cytotoxicity |
| 14-3-3 protein binding |
| integral component of lumenal side of endoplasmic reticulum membrane |
| positive regulation of natural killer cell mediated cytotoxicity |
| regulation of T cell cytokine production |
| positive regulation of natural killer cell mediated immunity |
| regulation of natural killer cell activation |
| peptide antigen binding |
| regulation of T cell mediated cytotoxicity |
| negative regulation of exocytosis |
| negative regulation of production of molecular mediator of immune response |
| negative regulation of lymphocyte mediated immunity |
| negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of natural killer cell mediated cytotoxicity |
| regulation of natural killer cell mediated immunity |
| negative regulation of adaptive immune response |
| positive regulation of T cell mediated immunity |
| negative regulation of leukocyte mediated immunity |
| regulation of leukocyte degranulation |
| positive regulation of regulated secretory pathway |
| ER to Golgi transport vesicle membrane |
| positive regulation of cytokine production involved in immune response |
| positive regulation of leukocyte mediated cytotoxicity |
| negative regulation of innate immune response |
| type I interferon signaling pathway |
| cellular response to type I interferon |
| positive regulation of cell killing |
| regulation of T cell mediated immunity |
| response to type I interferon |
| interferon-gamma-mediated signaling pathway |
| phagocytic vesicle membrane |
| antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| regulation of leukocyte mediated cytotoxicity |
| antigen processing and presentation of exogenous peptide antigen via MHC class I |
| recycling endosome membrane |
| regulation of cytokine production involved in immune response |
| positive regulation of exocytosis |
| negative regulation of response to biotic stimulus |
| positive regulation of production of molecular mediator of immune response |
| antigen processing and presentation of peptide antigen via MHC class I |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of cell killing |
| positive regulation of lymphocyte mediated immunity |
| positive regulation of adaptive immune response |
| negative regulation of immune effector process |
| positive regulation of leukocyte mediated immunity |
| regulation of production of molecular mediator of immune response |
| negative regulation of lymphocyte activation |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| negative regulation of immune response |
| regulation of lymphocyte mediated immunity |
| early endosome membrane |
| regulation of adaptive immune response |
| cellular response to interferon-gamma |
| regulation of regulated secretory pathway |
| negative regulation of leukocyte activation |
| antigen processing and presentation of exogenous peptide antigen |
| response to interferon-gamma |
| antigen processing and presentation of exogenous antigen |
| antigen processing and presentation of peptide antigen |
| negative regulation of cell activation |
| negative regulation of secretion by cell |
| regulation of leukocyte mediated immunity |
| negative regulation of neuron death |
| negative regulation of defense response |
| negative regulation of multi-organism process |
| antigen processing and presentation |
| positive regulation of immune effector process |
| regulation of exocytosis |
| negative regulation of secretion |
| negative regulation of cytokine production |
| lysosomal membrane |
| regulation of neuron death |
| signaling receptor binding |
| positive regulation of innate immune response |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| negative regulation of response to external stimulus |
| external side of plasma membrane |
| positive regulation of leukocyte activation |
| positive regulation of secretion by cell |
| positive regulation of cell activation |
| positive regulation of secretion |
| negative regulation of immune system process |
| positive regulation of cytokine production |
| regulation of innate immune response |
| regulation of immune effector process |
| positive regulation of defense response |
| negative regulation of transport |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| regulation of response to biotic stimulus |
| regulation of vesicle-mediated transport |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| cell surface |
| Golgi membrane |
| regulation of cell activation |
| cytokine-mediated signaling pathway |
| regulation of cytokine production |
| regulation of secretion by cell |
| regulation of defense response |
| innate immune response |
| regulation of multi-organism process |
| regulation of secretion |
| positive regulation of immune response |
| defense response to other organism |
| positive regulation of transport |
| negative regulation of cell death |
| cellular response to cytokine stimulus |
| endoplasmic reticulum |
| regulation of response to external stimulus |
| response to cytokine |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| regulation of response to stress |
| extracellular space |
| negative regulation of response to stimulus |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of multicellular organismal process |
| regulation of transport |
| immune response |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5746
- Expression level (log2 read counts): 4.62
Expression Distribution
HLA-F Expression in NALM6 Cells: 4.62
