HMGCLL1

Entrez Summary: N/A
UniProt Summary: Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. {ECO:0000269|PubMed:22847177, ECO:0000269|PubMed:22865860}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

hydroxymethylglutaryl-CoA lyase activity
leucine catabolic process
leucine metabolic process
ketone body biosynthetic process
cellular ketone body metabolic process
ketone body metabolic process
branched-chain amino acid catabolic process
branched-chain amino acid metabolic process
fatty acid derivative biosynthetic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
fatty acid derivative metabolic process
alpha-amino acid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
cellular amino acid metabolic process
generation of precursor metabolites and energy
small molecule catabolic process
drug metabolic process
small molecule biosynthetic process
perinuclear region of cytoplasm
carboxylic acid metabolic process
endoplasmic reticulum membrane
oxoacid metabolic process
endoplasmic reticulum
organic acid metabolic process
organonitrogen compound catabolic process
lipid metabolic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process
membrane