HMGN2 [The Human Chemical-Genetic Interaction Map Project]

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======= HMGN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HMGN2
  * **<color #00a2e8>Official Name</color>**: high mobility group nucleosomal binding domain 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3151|3151]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05204|P05204]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HMGN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HMGN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/163910|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HMG14 17|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleosomal DNA binding|
|killing of cells of other organism|
|disruption of cells of other organism|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|cell killing|
|antimicrobial humoral response|
|chromatin|
|modification of morphology or physiology of other organism|
|humoral immune response|
|interspecies interaction between organisms|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|RNA binding|
|extracellular space|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.83|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.75|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.76|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.76|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.77|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|1.85|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.87|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.9|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.13|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.13|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.19|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.22|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|2.23|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.5|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.78|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|3.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 68/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|6/28|
|bone|1/25|
|breast|7/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/15|
|kidney|3/21|
|liver|3/20|
|lung|7/75|
|lymphocyte|1/14|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|4/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|1/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7890
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HMGN2 Expression in NALM6 Cells: 9.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>