HMGN2

Entrez Summary: N/A
UniProt Summary: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cannabidiol 13μM R08 exp465	-1.83
Rifampicin 10μM R00 exp32	1.75
Alpha-Amanitin 0.5μM R00 exp5	1.76
Wortmannin 0.5μM R00 exp37	1.76
Dimethyloxaloylglycine 100μM R05 exp229	1.77
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	1.85
MLN-4924 0.2μM R00 exp21	1.87
UM0125461 0.74μM R02 exp84	1.9
Quercetin 20μM R08 exp517	2.13
RO-3307 4.7μM R02 exp80	2.13
LY2090314 0.003μM R08 exp499	2.19
I-BRD9 4μM R07 exp365	2.22
Dimethyl-Sulfoxide 1pc R03 exp120	2.23
LY2090314 0.003μM R08 exp500 no dilution day6	2.5
Olaparib 4μM R08 exp512	2.78
Vincristine 0.0005μM R04 exp190	3.53

Global Fraction of Cell Lines Where Essential: 68/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	6/28
bone	1/25
breast	7/33
central nervous system	4/56
cervix	0/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	2/15
kidney	3/21
liver	3/20
lung	7/75
lymphocyte	1/14
ovary	2/26
pancreas	1/24
peripheral nervous system	4/16
plasma cell	2/15
prostate	0/1
skin	2/24
soft tissue	1/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	1/5

Expression Distribution

nucleosomal DNA binding
killing of cells of other organism
disruption of cells of other organism
antimicrobial humoral immune response mediated by antimicrobial peptide
cell killing
antimicrobial humoral response
chromatin
modification of morphology or physiology of other organism
humoral immune response
interspecies interaction between organisms
response to other organism
response to external biotic stimulus
response to biotic stimulus
RNA binding
extracellular space
immune response