HMHA1 [The Human Chemical-Genetic Interaction Map Project]

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======= HMHA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARHGAP45
  * **<color #00a2e8>Official Name</color>**: Rho GTPase activating protein 45
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23526|23526]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92619|Q92619]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HMHA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HMHA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601155|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RhoGAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|azurophil granule lumen|
|ruffle membrane|
|secretory granule lumen|
|GTPase activator activity|
|regulation of small GTPase mediated signal transduction|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|exocytosis|
|leukocyte activation|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.69|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.09|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.05|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.82|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-1.79|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.74|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.74|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.74|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.77|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.78|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.8|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.84|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.85|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.86|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.93|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.93|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.96|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|2.11|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.27|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.55|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|2.64|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.96|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|3.59|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1152
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HMHA1 Expression in NALM6 Cells: 7.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>