HMX3

Entrez Summary: N/A
UniProt Summary: Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

embryo implantation
neuromuscular process controlling balance
maternal process involved in female pregnancy
inner ear morphogenesis
neuromuscular process
ear morphogenesis
female pregnancy
inner ear development
multi-multicellular organism process
ear development
sensory organ morphogenesis
embryonic organ morphogenesis
RNA polymerase II regulatory region sequence-specific DNA binding
embryonic organ development
sensory organ development
embryonic morphogenesis
brain development
head development
multicellular organismal reproductive process
multicellular organism reproduction
animal organ morphogenesis
embryo development
central nervous system development
multi-organism reproductive process
nervous system process
reproductive process
reproduction
DNA-binding transcription factor activity, RNA polymerase II-specific
system process