HNF4G

Gene Information

Official Symbol: HNF4G
Official Name: hepatocyte nuclear factor 4 gamma
Aliases and Previous Symbols: N/A
Entrez ID: 3174
UniProt: Q14541
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcription factor. Has a lower transcription activation potential than HNF4-alpha.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18863
Expression level (log2 read counts): -0.2

Expression Distribution

Hormone recep
zf-C4

steroid hormone receptor activity
steroid hormone mediated signaling pathway
hormone-mediated signaling pathway
transcription initiation from RNA polymerase II promoter
cellular response to steroid hormone stimulus
DNA-templated transcription, initiation
RNA polymerase II regulatory region sequence-specific DNA binding
response to steroid hormone
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
cellular response to lipid
cellular response to organic cyclic compound
cellular response to hormone stimulus
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
zinc ion binding
response to lipid
response to hormone
response to organic cyclic compound
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of transcription by RNA polymerase II
cellular response to endogenous stimulus
organic cyclic compound biosynthetic process
response to endogenous stimulus
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
positive regulation of RNA metabolic process
macromolecule biosynthetic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process