HNMT

Entrez Summary: In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. {ECO:0000269|PubMed:26206890}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

histamine N-methyltransferase activity
histamine catabolic process
histamine metabolic process
imidazole-containing compound catabolic process
histidine catabolic process
histidine metabolic process
response to tumor cell
imidazole-containing compound metabolic process
cellular biogenic amine catabolic process
amine catabolic process
neurotransmitter catabolic process
hyperosmotic response
response to immobilization stress
aromatic amino acid family catabolic process
aromatic amino acid family metabolic process
respiratory gaseous exchange by respiratory system
response to amine
response to cocaine
cellular biogenic amine metabolic process
cellular amine metabolic process
amine metabolic process
response to osmotic stress
response to anesthetic
neurotransmitter metabolic process
alpha-amino acid catabolic process
response to alkaloid
cellular amino acid catabolic process
response to glucocorticoid
response to corticosteroid
response to ammonium ion
ammonium ion metabolic process
response to interleukin-1
alpha-amino acid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
response to xenobiotic stimulus
cellular amino acid metabolic process
methylation
neuron projection
response to steroid hormone