HNRNPA0 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= HNRNPA0 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HNRNPA0
  * **<color #00a2e8>Official Name</color>**: heterogeneous nuclear ribonucleoprotein A0
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10949|10949]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13151|Q13151]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HNRNPA0&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HNRNPA0|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609409|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post- transcriptional regulation of cytokines mRNAs. {ECO:0000269|PubMed:12456657}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|AU-rich element binding|
|3-UTR-mediated mRNA stabilization|
|mRNA 3-UTR AU-rich region binding|
|mRNA stabilization|
|RNA stabilization|
|negative regulation of mRNA catabolic process|
|negative regulation of RNA catabolic process|
|negative regulation of mRNA metabolic process|
|ribonucleoprotein complex|
|mRNA binding|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|negative regulation of cellular catabolic process|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|negative regulation of catabolic process|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|regulation of mRNA metabolic process|
|RNA splicing|
|protein kinase binding|
|mRNA processing|
|inflammatory response|
|posttranscriptional regulation of gene expression|
|response to bacterium|
|mRNA metabolic process|
|regulation of cellular catabolic process|
|response to lipid|
|RNA processing|
|regulation of catabolic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|response to oxygen-containing compound|
|RNA metabolic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-2.87|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.54|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-2.14|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.12|
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.1|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.94|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.82|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.76|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.72|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.82|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.84|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.86|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18927
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HNRNPA0 Expression in NALM6 Cells: 8.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>