HNRNPA0

Entrez Summary: N/A
UniProt Summary: mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post- transcriptional regulation of cytokines mRNAs. {ECO:0000269|PubMed:12456657}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Etoposide 10μM R00 exp20	-2.87
Rotenone 2μM R00 exp33	-2.54
Phenformin 20μM R03 exp143	-2.14
Rapamycin 2μM R07 exp306	-2.12
MS023 2μM R03 exp134	-2.1
Etoposide 1μM R00 exp19	-1.94
Pyridostatin 4μM R05 exp240	-1.82
5-Fluorouracil 2μM R00 exp1	-1.76
Fluvastatin 2.2μM R06 exp282	1.72
DKK1 89ng/ml R08 exp477	1.82
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.84
Lapatinib 5μM R01 exp47	1.86
Cerivastatin 0.15μM R05 exp226	2.66

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	1/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

AU-rich element binding
3-UTR-mediated mRNA stabilization
mRNA 3-UTR AU-rich region binding
mRNA stabilization
RNA stabilization
negative regulation of mRNA catabolic process
negative regulation of RNA catabolic process
negative regulation of mRNA metabolic process
ribonucleoprotein complex
mRNA binding
regulation of mRNA stability
regulation of RNA stability
regulation of mRNA catabolic process
negative regulation of cellular catabolic process
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
negative regulation of catabolic process
response to lipopolysaccharide
response to molecule of bacterial origin
regulation of mRNA metabolic process
RNA splicing
protein kinase binding
mRNA processing
inflammatory response
posttranscriptional regulation of gene expression
response to bacterium
mRNA metabolic process
regulation of cellular catabolic process
response to lipid
RNA processing
regulation of catabolic process
response to other organism
response to external biotic stimulus
response to biotic stimulus
negative regulation of RNA metabolic process
defense response
RNA binding
negative regulation of nucleobase-containing compound metabolic process
response to oxygen-containing compound