HOXA13 [The Human Chemical-Genetic Interaction Map Project]

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======= HOXA13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HOXA13
  * **<color #00a2e8>Official Name</color>**: homeobox A13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3209|3209]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31271|P31271]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HOXA13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HOXA13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142959|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior- posterior axis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
|HoxA13 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sequence-specific DNA binding|
|skeletal system development|
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.28|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.05|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2.01|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.99|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.97|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.88|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.76|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.74|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.74|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.04|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.09|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|2.16|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|2.21|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.27|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.64|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|3.17|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|3.22|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|3.3|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|3.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12083
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HOXA13 Expression in NALM6 Cells: -1.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>