HPD

Entrez Summary: The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].
UniProt Summary: Key enzyme in the degradation of tyrosine.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
GSK626616 14μM R08 exp485	1.71
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	1.85

4-hydroxyphenylpyruvate dioxygenase activity
tyrosine catabolic process
tyrosine metabolic process
L-phenylalanine catabolic process
erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
L-phenylalanine metabolic process
erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process
aromatic amino acid family catabolic process
aromatic amino acid family metabolic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
drug catabolic process
alpha-amino acid metabolic process
organic acid catabolic process
carboxylic acid catabolic process
cellular amino acid metabolic process
small molecule catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
drug metabolic process
Golgi membrane
carboxylic acid metabolic process
endoplasmic reticulum membrane
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process