HPGDS

Entrez Summary: Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008].
UniProt Summary: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. {ECO:0000269|PubMed:10824118, ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:19939518, ECO:0000269|PubMed:9353279, ECO:0000269|PubMed:9425264}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GST C
GST N

prostaglandin-D synthase activity
negative regulation of male germ cell proliferation
negative regulation of germ cell proliferation
regulation of germ cell proliferation
regulation of male germ cell proliferation
cyclooxygenase pathway
prostaglandin biosynthetic process
prostanoid biosynthetic process
glutathione derivative metabolic process
glutathione derivative biosynthetic process
glutathione transferase activity
prostaglandin metabolic process
prostanoid metabolic process
unsaturated fatty acid biosynthetic process
icosanoid biosynthetic process
glutathione metabolic process
negative regulation of reproductive process
arachidonic acid metabolic process
fatty acid derivative biosynthetic process
unsaturated fatty acid metabolic process
icosanoid metabolic process
long-chain fatty acid metabolic process
fatty acid biosynthetic process
regulation of reproductive process
fatty acid derivative metabolic process
sulfur compound biosynthetic process
monocarboxylic acid biosynthetic process
locomotory behavior
cellular modified amino acid metabolic process
negative regulation of multi-organism process
magnesium ion binding
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
sulfur compound metabolic process
cofactor metabolic process
peptide metabolic process
monocarboxylic acid metabolic process
behavior
lipid biosynthetic process