HRH3

Gene Information

Official Symbol: HRH3
Official Name: histamine receptor H3
Aliases and Previous Symbols: N/A
Entrez ID: 11255
UniProt: Q9Y5N1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9544
Expression level (log2 read counts): -5.28

Expression Distribution

negative regulation of serotonin secretion
negative regulation of glutamate secretion
histamine receptor activity
regulation of serotonin secretion
G protein-coupled acetylcholine receptor activity
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
negative regulation of amino acid transport
regulation of norepinephrine secretion
regulation of glutamate secretion
G protein-coupled acetylcholine receptor signaling pathway
negative regulation of organic acid transport
negative regulation of neurotransmitter transport
negative regulation of amine transport
negative regulation of anion transport
acetylcholine receptor signaling pathway
regulation of amino acid transport
response to acetylcholine
cellular response to acetylcholine
G protein-coupled serotonin receptor signaling pathway
G protein-coupled serotonin receptor activity
neurotransmitter receptor activity
serotonin receptor signaling pathway
postsynaptic signal transduction
regulation of organic acid transport
regulation of catecholamine secretion
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
cellular response to dopamine
response to dopamine
signal transduction involved in cellular response to ammonium ion
regulation of amine transport
presynapse
regulation of anion transport
neurotransmitter secretion
signal release from synapse
cellular response to catecholamine stimulus
cellular response to monoamine stimulus
response to catecholamine
response to monoamine
cellular response to ammonium ion
regulation of neurotransmitter transport