HS3ST3B1

Entrez Summary: N/A
UniProt Summary: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non- anticoagulant heparan sulfate to anticoagulant heparan sulfate. {ECO:0000269|PubMed:10520990}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity
heparan sulfate proteoglycan biosynthetic process, enzymatic modification
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
protein sulfation
heparan sulfate sulfotransferase activity
sulfation
heparan sulfate proteoglycan biosynthetic process
heparan sulfate proteoglycan metabolic process
proteoglycan biosynthetic process
proteoglycan metabolic process
glycosaminoglycan biosynthetic process
aminoglycan biosynthetic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
glycoprotein biosynthetic process
sulfur compound metabolic process
glycoprotein metabolic process
Golgi membrane
carbohydrate derivative biosynthetic process
carbohydrate derivative metabolic process
integral component of plasma membrane
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process