HSD17B14

Entrez Summary: N/A
UniProt Summary: Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3- beta,17-beta-diol (in vitro). {ECO:0000269|PubMed:17067289}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nocodazole 0.1μM R03 exp94	-1.78
Alpha-Amanitin 0.5μM R00 exp5	-1.72

adh short
KR

testosterone 17-beta-dehydrogenase (NADP+) activity
estradiol 17-beta-dehydrogenase activity
estrogen biosynthetic process
steroid catabolic process
estrogen metabolic process
steroid hormone biosynthetic process
hormone biosynthetic process
cellular hormone metabolic process
steroid biosynthetic process
hormone metabolic process
steroid metabolic process
lipid catabolic process
organic cyclic compound catabolic process
regulation of hormone levels
lipid biosynthetic process
oxidation-reduction process
identical protein binding
lipid metabolic process
organic cyclic compound biosynthetic process
organic substance catabolic process