HSD17B3

Entrez Summary: This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 2008].
UniProt Summary: Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH. {ECO:0000269|PubMed:26545797}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

testosterone 17-beta-dehydrogenase (NADP+) activity
testosterone biosynthetic process
androgen biosynthetic process
male genitalia development
androgen metabolic process
ketone biosynthetic process
steroid hormone biosynthetic process
genitalia development
hormone biosynthetic process
cellular ketone metabolic process
cellular hormone metabolic process
steroid biosynthetic process
male sex differentiation
organic hydroxy compound biosynthetic process
hormone metabolic process
steroid metabolic process
sex differentiation
reproductive structure development
reproductive system development
organic hydroxy compound metabolic process
regulation of hormone levels
lipid biosynthetic process
small molecule biosynthetic process
developmental process involved in reproduction
intracellular membrane-bounded organelle
endoplasmic reticulum membrane
oxidation-reduction process
endoplasmic reticulum
lipid metabolic process
organic cyclic compound biosynthetic process
reproductive process
reproduction
small molecule metabolic process