HSD17B7

Entrez Summary: N/A
UniProt Summary: Responsible for the reduction of the keto group on the C-3 of sterols. {ECO:0000269|PubMed:12829805}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

KR
adh short

3-keto sterol reductase activity
estradiol 17-beta-dehydrogenase activity
estrogen biosynthetic process
estrogen metabolic process
cholesterol biosynthetic process
secondary alcohol biosynthetic process
steroid hormone biosynthetic process
sterol biosynthetic process
hormone biosynthetic process
alcohol biosynthetic process
cholesterol metabolic process
cellular hormone metabolic process
embryonic skeletal system development
steroid biosynthetic process
secondary alcohol metabolic process
sterol metabolic process
organic hydroxy compound biosynthetic process
hormone metabolic process
steroid metabolic process
alcohol metabolic process
organic hydroxy compound metabolic process
skeletal system development
regulation of hormone levels
lipid biosynthetic process
small molecule biosynthetic process
chordate embryonic development
embryo development ending in birth or egg hatching
endoplasmic reticulum membrane
oxidation-reduction process
embryo development
endoplasmic reticulum
lipid metabolic process
organic cyclic compound biosynthetic process
small molecule metabolic process