HSD3B2

Official Symbol: HSD3B2
Official Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
Aliases and Previous Symbols: N/A
Entrez ID: 3284
UniProt: P26439
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009].
UniProt Summary: 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cholesterol dehydrogenase activity
steroid delta-isomerase activity
mineralocorticoid biosynthetic process
3-beta-hydroxy-delta5-steroid dehydrogenase activity
mineralocorticoid metabolic process
smooth endoplasmic reticulum membrane
androgen biosynthetic process
glucocorticoid biosynthetic process
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
glucocorticoid metabolic process
response to corticosterone
androgen metabolic process
C21-steroid hormone metabolic process
response to mineralocorticoid
steroid hormone biosynthetic process
hormone biosynthetic process
mitochondrial intermembrane space
hippocampus development
mitochondrial membrane
limbic system development
oxidoreductase activity
cellular hormone metabolic process
steroid biosynthetic process
response to glucocorticoid
response to corticosteroid
pallium development
response to ketone
hormone metabolic process
response to alcohol
telencephalon development
steroid metabolic process
response to steroid hormone
forebrain development
mitochondrial inner membrane
regulation of hormone levels
lipid biosynthetic process
intracellular membrane-bounded organelle
brain development
head development
response to lipid