HSF1 [The Human Chemical-Genetic Interaction Map Project]

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======= HSF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HSF1
  * **<color #00a2e8>Official Name</color>**: heat shock transcription factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3297|3297]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q00613|Q00613]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HSF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/140580|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Function as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage (PubMed:1871105, PubMed:11447121, PubMed:1986252, PubMed:7760831, PubMed:7623826, PubMed:8946918, PubMed:8940068, PubMed:9341107, PubMed:9121459, PubMed:9727490, PubMed:9499401, PubMed:9535852, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:25963659, PubMed:26754925). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:9727490, PubMed:11583998, PubMed:16278218). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:1871105, PubMed:1986252, PubMed:8455624, PubMed:7935471, PubMed:7623826, PubMed:8940068, PubMed:9727490, PubMed:9499401, PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:25963659, PubMed:26754925). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Plays also several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Plays also a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage- dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Vert HS TF|
|HSF DNA-bind|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to nitroglycerin|
|translation elongation factor binding|
|response to diamide|
|cellular response to diamide|
|response to nitroglycerin|
|sequence-specific single stranded DNA binding|
|cellular response to L-glutamine|
|response to L-glutamine|
|response to hypobaric hypoxia|
|response to psychosocial stress|
|positive regulation of inclusion body assembly|
|positive regulation of mRNA polyadenylation|
|positive regulation of apoptotic DNA fragmentation|
|cellular response to sodium arsenite|
|nuclear stress granule|
|positive regulation of DNA catabolic process|
|positive regulation of microtubule binding|
|pronucleus|
|embryonic process involved in female pregnancy|
|response to sodium arsenite|
|negative regulation of double-strand break repair via nonhomologous end joining|
|cellular response to salt|
|regulation of protein heterodimerization activity|
|euchromatin|
|positive regulation of transcription from RNA polymerase II promoter in response to heat stress|
|STAT family protein binding|
|cellular response to potassium ion|
|regulation of microtubule binding|
|regulation of apoptotic DNA fragmentation|
|positive regulation of mRNA 3-end processing|
|negative regulation of inclusion body assembly|
|response to herbicide|
|regulation of DNA catabolic process|
|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|
|response to potassium ion|
|positive regulation of execution phase of apoptosis|
|regulation of inclusion body assembly|
|response to insecticide|
|regulation of mRNA polyadenylation|
|cellular response to arsenic-containing substance|
|response to salt|
|cellular response to angiotensin|
|negative regulation of cardiac muscle cell apoptotic process|
|regulation of double-strand break repair via nonhomologous end joining|
|negative regulation of striated muscle cell apoptotic process|
|mRNA transcription|
|response to angiotensin|
|heterochromatin|
|mitotic spindle pole|
|regulation of mRNA 3-end processing|
|cellular response to copper ion|
|cellular response to gamma radiation|
|positive regulation of multicellular organism growth|
|positive regulation of transcription from RNA polymerase II promoter in response to stress|
|female meiotic nuclear division|
|negative regulation of double-strand break repair|
|positive regulation of mRNA processing|
|response to arsenic-containing substance|
|protein homotrimerization|
|negative regulation of DNA repair|
|cellular response to estradiol stimulus|
|regulation of cardiac muscle cell apoptotic process|
|negative regulation of muscle cell apoptotic process|
|response to testosterone|
|cellular response to cadmium ion|
|regulation of striated muscle cell apoptotic process|
|regulation of execution phase of apoptosis|
|Hsp90 protein binding|
|response to copper ion|
|promoter-specific chromatin binding|
|protein trimerization|
|protein self-association|
|response to gamma radiation|
|heat shock protein binding|
|negative regulation of tumor necrosis factor production|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|response to cadmium ion|
|response to activity|
|regulation of multicellular organism growth|
|cellular response to nutrient|
|positive regulation of tyrosine phosphorylation of STAT protein|
|regulation of muscle cell apoptotic process|
|cellular response to ionizing radiation|
|cellular response to amino acid stimulus|
|cellular response to hydrogen peroxide|
|cellular response to heat|
|chromatin DNA binding|
|regulation of double-strand break repair|
|positive regulation of mRNA metabolic process|
|regulation of tyrosine phosphorylation of STAT protein|
|regulation of cellular response to heat|
|negative regulation of response to DNA damage stimulus|
|positive regulation of receptor signaling pathway via JAK-STAT|
|kinetochore|
|embryonic placenta development|
|positive regulation of receptor signaling pathway via STAT|
|condensed chromosome kinetochore|
|positive regulation of protein binding|
|response to antineoplastic agent|
|positive regulation of cold-induced thermogenesis|
|PML body|
|response to heat|
|response to amino acid|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|negative regulation of DNA metabolic process|
|regulation of DNA repair|
|regulation of DNA-templated transcription in response to stress|
|cellular response to unfolded protein|
|female gamete generation|
|regulation of receptor signaling pathway via JAK-STAT|
|cellular response to reactive oxygen species|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of receptor signaling pathway via STAT|
|response to estradiol|
|regulation of mRNA processing|
|regulation of cold-induced thermogenesis|
|response to ionizing radiation|
|regulation of tumor necrosis factor production|
|cellular response to topologically incorrect protein|
|positive regulation of mitotic cell cycle|
|positive regulation of cysteine-type endopeptidase activity|
|placenta development|
|meiotic nuclear division|
|regulation of tumor necrosis factor superfamily cytokine production|
|ribonucleoprotein complex|
|mRNA transport|
|response to unfolded protein|
|meiotic cell cycle process|
|positive regulation of developmental growth|
|positive regulation of endopeptidase activity|
|cellular response to radiation|
|response to temperature stimulus|
|positive regulation of binding|
|female pregnancy|
|cellular response to lipopolysaccharide|
|cellular response to xenobiotic stimulus|
|response to topologically incorrect protein|
|positive regulation of peptidyl-tyrosine phosphorylation|
|cellular response to molecule of bacterial origin|
|positive regulation of peptidase activity|
|nucleic acid transport|
|RNA transport|
|cellular response to metal ion|
|response to ketone|
|positive regulation of DNA metabolic process|
|establishment of RNA localization|
|response to reactive oxygen species|
|negative regulation of neuron death|
|cellular response to acid chemical|
|multi-multicellular organism process|
|cellular response to toxic substance|
|response to nutrient|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to biotic stimulus|
|RNA localization|
|regulation of response to DNA damage stimulus|
|regulation of protein binding|
|cellular response to inorganic substance|
|meiotic cell cycle|
|cellular response to nutrient levels|
|cellular response to oxidative stress|
|nucleobase-containing compound transport|
|regulation of cysteine-type endopeptidase activity|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of growth|
|cellular response to extracellular stimulus|
|cellular response to peptide hormone stimulus|
|negative regulation of cytokine production|
|nuclear division|
|response to xenobiotic stimulus|
|response to antibiotic|
|regulation of neuron death|
|organelle fission|
|response to lipopolysaccharide|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|response to molecule of bacterial origin|
|cellular response to peptide|
|regulation of mRNA metabolic process|
|regulation of developmental growth|
|cellular response to external stimulus|
|protein homooligomerization|
|response to hypoxia|
|response to acid chemical|
|cellular process involved in reproduction in multicellular organism|
|regulation of DNA metabolic process|
|positive regulation of proteolysis|
|response to decreased oxygen levels|
|positive regulation of cellular catabolic process|
|response to metal ion|
|MAPK cascade|
|positive regulation of cell cycle|
|regulation of binding|
|in utero embryonic development|
|response to oxygen levels|
|response to oxidative stress|
|response to peptide hormone|
|signal transduction by protein phosphorylation|
|cellular response to drug|
|regulation of endopeptidase activity|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|positive regulation of catabolic process|
|embryonic organ development|
|response to radiation|
|regulation of peptidase activity|
|protein kinase binding|
|response to peptide|
|mRNA processing|
|protein heterodimerization activity|
|centrosome|
|response to nutrient levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to toxic substance|
|DNA repair|
|protein complex oligomerization|
|cellular response to lipid|
|positive regulation of cellular component biogenesis|
|response to extracellular stimulus|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|spermatogenesis|
|male gamete generation|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|regulation of growth|
|negative regulation of cell population proliferation|
|DNA-binding transcription factor activity|
|response to bacterium|
|gamete generation|
|mRNA metabolic process|
|regulation of cytokine production|
|positive regulation of cell death|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of proteolysis|
|regulation of cellular response to stress|
|DNA metabolic process|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|RNA processing|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|embryo development|
|negative regulation of cell death|
|multi-organism reproductive process|
|regulation of catabolic process|
|cell cycle process|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|response to drug|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of hydrolase activity|
|phosphorylation|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|cell cycle|
|defense response|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-2.13|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.95|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.92|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.91|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-1.75|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.71|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.71|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.73|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.78|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.81|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.81|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.88|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.88|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.89|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.91|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.96|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.96|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.98|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.01|
|[[:results:exp358|FK-506 5μM R07 exp358]]|2.04|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.14|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|2.2|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|3.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 49/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|1/28|
|bone|0/26|
|breast|4/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|3/20|
|lung|4/75|
|lymphocyte|1/16|
|ovary|3/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1662
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HSF1 Expression in NALM6 Cells: 6.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>