HSF4

Entrez Summary: Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008].
UniProt Summary: DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription. {ECO:0000269|PubMed:16371476}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of transcription from RNA polymerase II promoter in response to heat stress
histone H3-K9 demethylation
histone lysine demethylation
histone demethylation
protein dealkylation
positive regulation of transcription from RNA polymerase II promoter in response to stress
protein demethylation
protein homotrimerization
protein trimerization
demethylation
cellular response to heat
response to heat
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of DNA-templated transcription in response to stress
response to temperature stimulus
visual perception
sensory perception of light stimulus
transcription corepressor activity
camera-type eye development
protein homooligomerization
eye development
visual system development
histone modification
sensory system development
covalent chromatin modification
nuclear speck
sequence-specific DNA binding
RNA polymerase II proximal promoter sequence-specific DNA binding
protein complex oligomerization
sensory organ development
DNA-binding transcription factor activity
chromatin organization
negative regulation of transcription by RNA polymerase II
positive regulation of cell population proliferation
positive regulation of cell differentiation
sensory perception
chromosome organization
response to abiotic stimulus
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II