HTR1D

Entrez Summary: N/A
UniProt Summary: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction. {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1652050}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

7tm 1
7TM GPCR Srsx

intestine smooth muscle contraction
gastro-intestinal system smooth muscle contraction
phasic smooth muscle contraction
vasoconstriction
G protein-coupled serotonin receptor activity
G protein-coupled serotonin receptor signaling pathway
neurotransmitter receptor activity
negative regulation of blood vessel diameter
serotonin receptor signaling pathway
smooth muscle contraction
regulation of behavior
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
cellular response to dopamine
response to dopamine
signal transduction involved in cellular response to ammonium ion
cellular response to catecholamine stimulus
cellular response to monoamine stimulus
response to catecholamine
response to monoamine
cellular response to ammonium ion
regulation of blood vessel diameter
regulation of tube diameter
regulation of tube size
vascular process in circulatory system
response to ammonium ion
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
muscle contraction
muscle system process
blood circulation
circulatory system process
cellular response to drug
anterograde trans-synaptic signaling
dendrite
chemical synaptic transmission
trans-synaptic signaling
synaptic signaling
regulation of anatomical structure size
cellular response to organic cyclic compound
cellular response to organonitrogen compound