HTR4

Entrez Summary: This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of appetite
G protein-coupled serotonin receptor signaling pathway
G protein-coupled serotonin receptor activity
neurotransmitter receptor activity
serotonin receptor signaling pathway
cellular response to dopamine
response to dopamine
signal transduction involved in cellular response to ammonium ion
cellular response to monoamine stimulus
cellular response to catecholamine stimulus
response to monoamine
response to catecholamine
cellular response to ammonium ion
response to ammonium ion
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
endosome
cellular response to drug
chemical synaptic transmission
anterograde trans-synaptic signaling
dendrite
trans-synaptic signaling
synaptic signaling
response to nutrient levels
response to extracellular stimulus
cellular response to organic cyclic compound
cellular response to organonitrogen compound
cellular response to nitrogen compound
G protein-coupled receptor activity
response to organic cyclic compound
response to organonitrogen compound
response to drug
cellular response to oxygen-containing compound
response to nitrogen compound
cell-cell signaling
cellular response to endogenous stimulus
G protein-coupled receptor signaling pathway
integral component of plasma membrane
response to endogenous stimulus
response to oxygen-containing compound
membrane