HTRA1

Gene Information

Official Symbol: HTRA1
Official Name: HtrA serine peptidase 1
Aliases and Previous Symbols: N/A
Entrez ID: 5654
UniProt: Q92743
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008].
UniProt Summary: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. {ECO:0000269|PubMed:16377621, ECO:0000269|PubMed:20671064, ECO:0000269|PubMed:9852107}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15156
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
Isoniazid 100μM R08 exp494	-1.77
Amiloride 100μM R08 exp447	-1.74

PDZ
IGFBP
Kazal 2
Trypsin
Kazal 1

chorionic trophoblast cell differentiation
dentinogenesis
chorion development
extraembryonic membrane development
insulin-like growth factor binding
negative regulation of defense response to virus
negative regulation of BMP signaling pathway
serine-type peptidase activity
extracellular matrix disassembly
negative regulation of transforming growth factor beta receptor signaling pathway
regulation of defense response to virus
negative regulation of cellular response to transforming growth factor beta stimulus
odontogenesis of dentin-containing tooth
regulation of BMP signaling pathway
negative regulation of response to biotic stimulus
regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
odontogenesis
negative regulation of immune effector process
negative regulation of cellular response to growth factor stimulus
placenta development
serine-type endopeptidase activity
positive regulation of epithelial cell proliferation
negative regulation of defense response
negative regulation of multi-organism process
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to growth factor stimulus
regulation of epithelial cell proliferation
extracellular matrix organization
collagen-containing extracellular matrix
negative regulation of response to external stimulus
extracellular structure organization
cellular component disassembly
reproductive structure development
reproductive system development
negative regulation of immune system process
regulation of immune effector process
regulation of response to biotic stimulus
developmental process involved in reproduction