HVCN1

Entrez Summary: N/A
UniProt Summary: Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. {ECO:0000269|PubMed:16554753, ECO:0000269|PubMed:20037153, ECO:0000269|PubMed:22020278}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Pimelic-diphenylamide-106 5μM R00 exp28	-1.7
Methotrexate 0.01μM R08 exp501	1.75
UM131593 0.1μM R01 exp58	2.02

voltage-gated proton channel activity
voltage-gated cation channel activity
cellular response to pH
cellular response to zinc ion
response to pH
sperm-egg recognition
response to zinc ion
cell-cell recognition
phagocytic vesicle membrane
cell redox homeostasis
specific granule membrane
secretory granule membrane
single fertilization
proton transmembrane transport
fertilization
cellular response to metal ion
cellular response to inorganic substance
cell recognition
cellular response to environmental stimulus
cellular response to abiotic stimulus
response to metal ion
monovalent inorganic cation transport
regulation of ion transmembrane transport
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
response to inorganic substance
inorganic cation transmembrane transport
regulation of transmembrane transport
myeloid leukocyte activation
cation transmembrane transport
leukocyte activation involved in immune response
cell activation involved in immune response
inorganic ion transmembrane transport
regulation of ion transport