HYAL3

Entrez Summary: N/A
UniProt Summary: Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro. {ECO:0000250|UniProtKB:Q8VEI3}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ovarian follicle atresia
positive regulation of acrosomal vesicle exocytosis
negative regulation of ovarian follicle development
hyaluronoglucuronidase activity
regulation of acrosomal vesicle exocytosis
negative regulation of female gonad development
negative regulation of gonad development
regulation of ovarian follicle development
penetration of zona pellucida
hyalurononglucosaminidase activity
cellular response to UV-B
positive regulation of acrosome reaction
regulation of female gonad development
positive regulation of fertilization
hyaluronan catabolic process
response to UV-B
regulation of acrosome reaction
acrosomal membrane
regulation of gonad development
positive regulation of calcium ion-dependent exocytosis
sperm midpiece
regulation of fertilization
hyaluronan metabolic process
regulation of calcium ion-dependent exocytosis
positive regulation of regulated secretory pathway
negative regulation of reproductive process
glycosaminoglycan catabolic process
aminoglycan catabolic process
virus receptor activity
positive regulation of reproductive process
cellular response to UV
acrosomal vesicle
female gonad development
positive regulation of exocytosis
development of primary female sexual characteristics
viral entry into host cell
entry into host cell
entry into host
female sex differentiation
mucopolysaccharide metabolic process