IAPP [The Human Chemical-Genetic Interaction Map Project]

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======= IAPP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IAPP
  * **<color #00a2e8>Official Name</color>**: islet amyloid polypeptide
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3375|3375]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10997|P10997]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IAPP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IAPP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147940|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Calc CGRP IAPP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of amyloid fibril formation|
|amylin receptor signaling pathway|
|calcitonin family receptor signaling pathway|
|regulation of amyloid fibril formation|
|positive regulation of protein kinase A signaling|
|negative regulation of protein homooligomerization|
|negative regulation of bone resorption|
|negative regulation of bone remodeling|
|negative regulation of protein oligomerization|
|regulation of protein homooligomerization|
|regulation of protein kinase A signaling|
|negative regulation of tissue remodeling|
|eating behavior|
|regulation of bone resorption|
|regulation of protein oligomerization|
|regulation of bone remodeling|
|negative regulation of mitochondrion organization|
|regulation of tissue remodeling|
|sensory perception of pain|
|amyloid-beta binding|
|feeding behavior|
|hormone activity|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein complex assembly|
|cAMP-mediated signaling|
|positive regulation of protein kinase B signaling|
|cyclic-nucleotide-mediated signaling|
|regulation of mitochondrion organization|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of protein kinase B signaling|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|positive regulation of cytosolic calcium ion concentration|
|regulation of cytosolic calcium ion concentration|
|signaling receptor binding|
|second-messenger-mediated signaling|
|protein homooligomerization|
|regulation of supramolecular fiber organization|
|neuronal cell body|
|negative regulation of organelle organization|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|regulation of protein complex assembly|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|protein complex oligomerization|
|positive regulation of MAPK cascade|
|cellular metal ion homeostasis|
|behavior|
|metal ion homeostasis|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|cation homeostasis|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|ion homeostasis|
|cellular homeostasis|
|apoptotic process|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|sensory perception|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|positive regulation of phosphorylation|
|identical protein binding|
|cell death|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|regulation of organelle organization|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.2|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.99|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16002
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IAPP Expression in NALM6 Cells: 1.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>