IAPP
Gene Information
- Official Symbol: IAPP
- Official Name: islet amyloid polypeptide
- Aliases and Previous Symbols: N/A
- Entrez ID: 3375
- UniProt: P10997
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
Pfam Domains GO Terms
Pfam Domains
| Calc CGRP IAPP |
GO Terms
| negative regulation of amyloid fibril formation |
| amylin receptor signaling pathway |
| calcitonin family receptor signaling pathway |
| regulation of amyloid fibril formation |
| positive regulation of protein kinase A signaling |
| negative regulation of protein homooligomerization |
| negative regulation of bone resorption |
| negative regulation of bone remodeling |
| negative regulation of protein oligomerization |
| regulation of protein homooligomerization |
| regulation of protein kinase A signaling |
| negative regulation of tissue remodeling |
| eating behavior |
| regulation of bone resorption |
| regulation of protein oligomerization |
| regulation of bone remodeling |
| negative regulation of mitochondrion organization |
| regulation of tissue remodeling |
| sensory perception of pain |
| amyloid-beta binding |
| feeding behavior |
| hormone activity |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| negative regulation of supramolecular fiber organization |
| negative regulation of protein complex assembly |
| cAMP-mediated signaling |
| positive regulation of protein kinase B signaling |
| cyclic-nucleotide-mediated signaling |
| regulation of mitochondrion organization |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| regulation of protein kinase B signaling |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| positive regulation of cytosolic calcium ion concentration |
| regulation of cytosolic calcium ion concentration |
| signaling receptor binding |
| second-messenger-mediated signaling |
| protein homooligomerization |
| regulation of supramolecular fiber organization |
| neuronal cell body |
| negative regulation of organelle organization |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| regulation of protein complex assembly |
| cellular divalent inorganic cation homeostasis |
| divalent inorganic cation homeostasis |
| protein complex oligomerization |
| positive regulation of MAPK cascade |
| cellular metal ion homeostasis |
| behavior |
| metal ion homeostasis |
| cellular cation homeostasis |
| positive regulation of apoptotic process |
| cellular ion homeostasis |
| positive regulation of programmed cell death |
| positive regulation of cell death |
| negative regulation of cellular component organization |
| cation homeostasis |
| negative regulation of cell differentiation |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| regulation of MAPK cascade |
| ion homeostasis |
| cellular homeostasis |
| apoptotic process |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| sensory perception |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| programmed cell death |
| positive regulation of phosphorylation |
| identical protein binding |
| cell death |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| regulation of organelle organization |
| G protein-coupled receptor signaling pathway |
| nervous system process |
| regulation of protein phosphorylation |
| regulation of apoptotic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| extracellular region |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Ammonium tetrathiomolybdate 10μM R08 exp448 | -2.2 |
| Tozasertib 0.1μM R07 exp414 | -1.99 |
| Dimethyl-Sulfoxide 1pc R03 exp120 | 1.96 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16002
- Expression level (log2 read counts): 1.75
Expression Distribution
IAPP Expression in NALM6 Cells: 1.75
