IBTK

Gene Information

Official Symbol: IBTK
Official Name: inhibitor of Bruton tyrosine kinase
Aliases and Previous Symbols: N/A
Entrez ID: 25998
UniProt: Q9P2D0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6808
Expression level (log2 read counts): 6.67

Expression Distribution

Screen	Score
VHL-ligand-1 20μM R07 exp421	-1.88
Trimetrexate 0.03μM R08 exp535	2.03

Ank 2
BTB
RCC1

protein tyrosine kinase inhibitor activity
negative regulation of protein tyrosine kinase activity
negative regulation of peptidyl-tyrosine phosphorylation
release of sequestered calcium ion into cytosol
negative regulation of sequestering of calcium ion
calcium ion transmembrane import into cytosol
calcium ion transport into cytosol
cytosolic calcium ion transport
regulation of protein tyrosine kinase activity
regulation of sequestering of calcium ion
calcium ion transmembrane transport
negative regulation of protein kinase activity
negative regulation of kinase activity
calcium ion transport
regulation of peptidyl-tyrosine phosphorylation
negative regulation of transferase activity
positive regulation of cytosolic calcium ion concentration
divalent metal ion transport
divalent inorganic cation transport
regulation of cytosolic calcium ion concentration
negative regulation of protein phosphorylation
cellular calcium ion homeostasis
negative regulation of phosphorylation
calcium ion homeostasis
protein kinase binding
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
cellular metal ion homeostasis
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
inorganic cation transmembrane transport
negative regulation of protein modification process
cation transmembrane transport
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
cation homeostasis
inorganic ion homeostasis