ICAM2

Entrez Summary: N/A
UniProt Summary: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen- specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

uropod
cleavage furrow
microvillus
stimulatory C-type lectin receptor signaling pathway
innate immune response activating cell surface receptor signaling pathway
integrin binding
innate immune response-activating signal transduction
activation of innate immune response
extracellular matrix organization
positive regulation of innate immune response
positive regulation of response to biotic stimulus
extracellular structure organization
immune response-activating cell surface receptor signaling pathway
regulation of innate immune response
positive regulation of defense response
immune response-regulating cell surface receptor signaling pathway
cell-cell adhesion
positive regulation of multi-organism process
regulation of response to biotic stimulus
immune response-activating signal transduction
immune response-regulating signaling pathway
positive regulation of response to external stimulus
activation of immune response
regulation of defense response
regulation of multi-organism process
positive regulation of immune response
cell adhesion
biological adhesion
regulation of response to external stimulus
positive regulation of immune system process
regulation of immune response
integral component of plasma membrane
regulation of response to stress
regulation of immune system process
membrane