ICOS

Entrez Summary: The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008].
UniProt Summary: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). {ECO:0000250, ECO:0000269|PubMed:11169414, ECO:0000269|PubMed:9930702}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

T cell tolerance induction
tolerance induction
T cell costimulation
lymphocyte costimulation
positive regulation of protein kinase B signaling
positive regulation of T cell activation
positive regulation of leukocyte cell-cell adhesion
regulation of protein kinase B signaling
positive regulation of cell-cell adhesion
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
positive regulation of lymphocyte activation
external side of plasma membrane
regulation of cell-cell adhesion
positive regulation of leukocyte activation
positive regulation of cell adhesion
positive regulation of cell activation
cell-cell adhesion
regulation of lymphocyte activation
regulation of leukocyte activation
regulation of cell activation
immune system development
regulation of cell adhesion
cell adhesion
biological adhesion
positive regulation of intracellular signal transduction
positive regulation of immune system process
integral component of plasma membrane
positive regulation of signal transduction
regulation of immune system process
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
immune response
extracellular region