ICOSLG [The Human Chemical-Genetic Interaction Map Project]

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======= ICOSLG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ICOSLG
  * **<color #00a2e8>Official Name</color>**: inducible T cell costimulator ligand
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23308|23308]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75144|O75144]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ICOSLG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ICOSLG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605717|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2-set 2|
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of activated T cell proliferation|
|hyperosmotic response|
|regulation of activated T cell proliferation|
|T cell costimulation|
|lymphocyte costimulation|
|cytoplasmic ribonucleoprotein granule|
|response to osmotic stress|
|positive regulation of T cell proliferation|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|B cell activation|
|regulation of T cell proliferation|
|T cell receptor signaling pathway|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|T cell activation|
|positive regulation of cell-cell adhesion|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|signaling receptor binding|
|positive regulation of lymphocyte activation|
|lymphocyte activation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|immune response-activating cell surface receptor signaling pathway|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of lymphocyte activation|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|adaptive immune response|
|activation of immune response|
|regulation of cell activation|
|regulation of cell adhesion|
|positive regulation of immune response|
|positive regulation of cell population proliferation|
|leukocyte activation|
|identical protein binding|
|cell activation|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|defense response|
|regulation of cell population proliferation|
|regulation of immune system process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17418
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ICOSLG Expression in NALM6 Cells: 6.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>