ICOSLG

Entrez Summary: N/A
UniProt Summary: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

C2-set 2
V-set

positive regulation of activated T cell proliferation
hyperosmotic response
regulation of activated T cell proliferation
T cell costimulation
lymphocyte costimulation
cytoplasmic ribonucleoprotein granule
response to osmotic stress
positive regulation of T cell proliferation
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
positive regulation of leukocyte proliferation
B cell activation
regulation of T cell proliferation
T cell receptor signaling pathway
positive regulation of T cell activation
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
positive regulation of leukocyte cell-cell adhesion
regulation of leukocyte proliferation
T cell activation
positive regulation of cell-cell adhesion
antigen receptor-mediated signaling pathway
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
signaling receptor binding
positive regulation of lymphocyte activation
lymphocyte activation
external side of plasma membrane
regulation of cell-cell adhesion
positive regulation of cell adhesion
positive regulation of leukocyte activation
positive regulation of cell activation
immune response-activating cell surface receptor signaling pathway
immune response-regulating cell surface receptor signaling pathway
regulation of lymphocyte activation
immune response-activating signal transduction
immune response-regulating signaling pathway
regulation of leukocyte activation
adaptive immune response
activation of immune response