IFI30

Entrez Summary: N/A
UniProt Summary: Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II- restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

oxidoreductase activity, acting on a sulfur group of donors
interferon-gamma-mediated signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class I
lysosomal lumen
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
cellular response to interferon-gamma
antigen processing and presentation of exogenous peptide antigen
response to interferon-gamma
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
antigen processing and presentation
lysosome
cell junction
cytokine-mediated signaling pathway
intracellular membrane-bounded organelle
innate immune response
defense response to other organism
oxidation-reduction process
cellular response to cytokine stimulus
response to cytokine
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
immune response
extracellular region