IFITM5

• Official Symbol: IFITM5
• Official Name: interferon induced transmembrane protein 5
• Aliases and Previous Symbols: N/A
• Entrez ID: 387733
• UniProt: A6NNB3
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a membrane protein thought to play a role in bone mineralization. This gene is located on chromosome 11 in a cluster of related genes which are induced by interferon, however, this gene has not been shown to be interferon inducible. A similar gene, located in a gene cluster on mouse chromosome 7, is a member of the interferon-inducible fragilis gene family. The mouse gene encodes a transmembrane protein described as participating in germ cell competence. A mutation in the 5' UTR of this gene has been associated with osteogenesis imperfecta type V (PMID: 22863190, 22863195). [provided by RefSeq, Aug 2012].
• UniProt Summary: Required for normal bone mineralization. {ECO:0000269|PubMed:24519609}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 9238
• Expression level (log2 read counts): -6.6

Expression Distribution

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IFITM5 Expression in NALM6 Cells: -6.6