IFT172 [The Human Chemical-Genetic Interaction Map Project]

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======= IFT172 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IFT172
  * **<color #00a2e8>Official Name</color>**: intraflagellar transport 172
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26160|26160]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UG01|Q9UG01]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IFT172&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IFT172|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607386|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of the intraflagellar transport subcomplex IFT-B. Subcomplexes IFT-A and IFT-B are necessary for ciliary assembly and maintenance. Mutations in this gene have been associated with skeletal ciliopathies, with or without polydactyly, such as such short-rib thoracic dysplasias 1, 9 or 10. [provided by RefSeq, Mar 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity). {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
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<modal id='GO_terms' size='lg' title='GO Terms'>
|sperm cytoplasmic droplet|
|hindgut development|
|left/right axis specification|
|left/right pattern formation|
|intraciliary transport particle B|
|sperm principal piece|
|sperm midpiece|
|positive regulation of smoothened signaling pathway|
|spinal cord motor neuron differentiation|
|intraciliary transport involved in cilium assembly|
|ciliary tip|
|non-motile cilium assembly|
|ventral spinal cord development|
|intraciliary transport|
|cytoplasmic microtubule organization|
|cell differentiation in spinal cord|
|extracellular vesicle|
|heart looping|
|determination of heart left/right asymmetry|
|embryonic heart tube morphogenesis|
|protein transport along microtubule|
|microtubule-based protein transport|
|smoothened signaling pathway|
|embryonic heart tube development|
|regulation of smoothened signaling pathway|
|dorsal/ventral pattern formation|
|axis specification|
|roof of mouth development|
|neural tube closure|
|tube closure|
|primary neural tube formation|
|axoneme|
|neural tube formation|
|spinal cord development|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|embryonic epithelial tube formation|
|negative regulation of epithelial cell proliferation|
|specification of symmetry|
|Notch signaling pathway|
|digestive tract development|
|epithelial tube formation|
|ciliary basal body|
|digestive system development|
|morphogenesis of embryonic epithelium|
|tube formation|
|transport along microtubule|
|protein processing|
|neural tube development|
|cytoskeleton-dependent intracellular transport|
|central nervous system neuron differentiation|
|limb development|
|appendage development|
|microtubule-based transport|
|cilium|
|bone development|
|protein maturation|
|heart morphogenesis|
|protein-containing complex localization|
|microtubule-based movement|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|regionalization|
|regulation of epithelial cell proliferation|
|cilium assembly|
|cilium organization|
|epidermis development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|plasma membrane bounded cell projection assembly|
|supramolecular fiber organization|
|cell projection assembly|
|microtubule cytoskeleton organization|
|skeletal system development|
|heart development|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|microtubule-based process|
|negative regulation of cell population proliferation|
|brain development|
|organelle assembly|
|head development|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|intracellular protein transport|
|neuron differentiation|
|cytoskeleton organization|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|proteolysis|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of signal transduction|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6134
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IFT172 Expression in NALM6 Cells: 2.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>